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Author

Georg Schmidt

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Review Open access Oct 2026

Academic treatment optimization studies in oncology and internal medicine: a risk- and burden-adapted regulatory framework for the European Union

Summary Academic treatment optimization studies (TOS) play an important role in determining how established and emerging treatments should be combined, sequenced, intensified, de-intensified, or otherwise optimized in routine clinical care. Unlike commercial clinical trials, which primarily support the development and...

W. E. Berdel, M. Dreyling, M. Schrappe et al. · 0 citations
Open access Aug 2026

Mortality reduction with implanted defibrillator for primary prevention of sudden death after Myocardial Infarction: temporal trends in the PROFID study.

In this analysis including a large cohort of post-myocardial infarction patients with reduced LVEF, the estimated mortality reduction associated with primary prevention ICD implantation progressively decreased over time.

Alireza Sepehri Shamloo, T. Chiba, J. G. Tijssen et al. · 0 citations

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