Review
Open access
Sep 2026
From chemical space to synthetic reality: A framework for makeable-by-design generative AI in drug discovery.
Generative artificial intelligence (AI) is reshaping molecular design, but many outputs are still judged by proxy metrics that do not establish whether proposed compounds can be synthesized, tested and advanced. This review reframes the field around 'synthetic reality': the extent to which AI-generated molecules surviv...
Sebastián O. Simonetti, Aldana B. Moroni, M. Zanardi et al.
· Drug Discovery Today · 0 citations