Liver diseases driven by metabolic dysfunction, inflammation, and fibrosis such as metabolic dysfunction-associated steatotic liver disease (MASLD), including metabolic dysfunction-associated steatohepatitis (MASH), and acute liver injury represent a growing global health burden. The zinc finger protein Zfp697 (ZNF697...
S. Præstholm, J. Correia, Rafael Hoyos Justiniano et al.· Molecular Metabolism· 0 citations
In the nervous system, aging causes deterioration of cellular and molecular processes that are associated with declines in cognition, sensory perception, and motor coordination. Aging is also the strongest risk factor for neurodegenerative disease, yet the mechanisms by which aging predisposes neurons to dysfunction re...
Sawyer Randles, Gene W. Yeo· Trends in Cell Biology· 0 citations
ESAPE (Endogenous Site-specific Competition Assays using Prime Editors using Prime Editors), a platform for the site-resolved functional analysis of covalent ligands in cells, identifies multiple covalent ligand-protein interactions that impair cancer cell growth.
Jason Tse, William R. Brothers, Rachel E. Hayward et al.· bioRxiv· 0 citations
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