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Author

Gen-Ping Xue

2 papers indexed here

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Sep 2026

Highly Potent and Selective TRPM2 Inhibitors: Therapeutic Effects and Mechanisms in Acute Lung Injury.

Acute lung injury (ALI) remains a clinical challenge due to scarce therapeutic targets and insufficient drug specificity, with lipopolysaccharide (LPS) as a key inducer of infection-related ALI. The transient receptor potential melastatin 2 (TRPM2) channel mediates pulmonary inflammation, oxidative stress and apoptosis...

Han Zhang, Hui-Jian Zeng, Jia-Qi Han et al. · 0 citations
Open access Sep 2026

Novel Dissymmetric Ionizable Lipid-Assembled Lipid Nanoparticles for Delivery of Ferroptosis-Related siRNA in Diabetic Treatment

Small interfering RNA (siRNA) enables precise post-transcriptional gene silencing for refractory diseases, yet its clinical translation remains limited by the lack of safe and efficient delivery vectors. Inspired by the dissymmetric alkyl chain architecture of natural membrane phospholipids, we designed and synthesized...

Han Zhang, Yuan-Yuan Liu, Feng-Yang He et al. · 0 citations

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