Highly Potent and Selective TRPM2 Inhibitors: Therapeutic Effects and Mechanisms in Acute Lung Injury.
Acute lung injury (ALI) remains a clinical challenge due to scarce therapeutic targets and insufficient drug specificity, with lipopolysaccharide (LPS) as a key inducer of infection-related ALI. The transient receptor potential melastatin 2 (TRPM2) channel mediates pulmonary inflammation, oxidative stress and apoptosis...