Timing the Alzheimer's disease pathological cascade.
This scientific commentary refers to ‘Modelling the temporal evolution of plasma p-tau217, amyloid PET, tau PET and cognition’ by Cogswell et al. (https://doi.org/10.1093/brain/awag075).
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This scientific commentary refers to ‘Modelling the temporal evolution of plasma p-tau217, amyloid PET, tau PET and cognition’ by Cogswell et al. (https://doi.org/10.1093/brain/awag075).
In this large longitudinal sample of asymptomatic individuals, the Aβ-dominant biomarker component showed the strongest association with longitudinal GM atrophy and cognitive decline, beyond the effects of tau pathophysiology and neuroaxonal injury.
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