Author

Ge Zhang

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Open access Oct 2026

Microenvironment-Triggered Sequentially Targeted Micelles for Dual Regulation of Macrophages and Fibroblast-Like Synoviocytes via ROS-Responsive Rg1 Release and HAP-1-Mediated Celastrol Delivery in Rheumatoid Arthritis Therapy.

Introduction Excessive proliferation of invasive fibroblast-like synoviocytes (FLS) and persistent synovial inflammation inevitably drive the pathological progression of rheumatoid arthritis (RA). A drug delivery system enabling dual regulation of macrophages and FLS is highly desirable for RA treatment. Methods We f...

Ya-Ni Zhang, Rui-Bo Guo, Ying Zheng et al. · International Journal of Nan... · 0 citations

Open access Aug 2026

Microglia-targeted Panax notoginseng polysaccharide nanoparticles alleviate Alzheimer's disease via AMPK-mTOR/HIF-1α-mediated immunometabolic reprogramming

Alzheimer's disease (AD) is increasingly recognized as an immunometabolic disorder characterized by a self-reinforcing cycle of neuroinflammation and glycolytic reprogramming in microglia. Herein, we developed KPBIT@NPs, a microglia-targeted polysaccharide-based nanomedicine. Unlike many conventional nanocarriers that...

Ge Zhang, Liang Kong, Ruihan Guo et al. · Materials Today Bio · 0 citations

Open access Aug 2026

AB4-Loaded Nanomicelle Hydrogel Promotes Targeting of the Dysregulated Diabetic Wound Microenvironment via Coordinated Multistage Repair

This nanocomposite hydrogel integrating a bioactive carrier with a therapeutic payload to enable coordinated intervention across multiple phases of diabetic wound repair offers a promising strategy for the treatment of chronic diabetic wounds.

Xue Shao, De-Jin Ma, Ya-Ni Zhang et al. · Gels · 0 citations