Open access
Aug 2026
RMI2 depletion recovers cGAS-STING signaling to enhance immunotherapy in colorectal cancer
Microsatellite-stable (MSS) colorectal cancers (CRCs) are largely refractory to immune checkpoint inhibitors (ICIs) due to immunologically “cold” tumor microenvironments (TMEs) characterized by limited T-cell infiltration. While RecQ-mediated genome instability 2 (RMI2) is known for regulating DNA repair, its role in...
Run-Kai Cai, E. Huang, Yina Liu et al.
· Cell Death & Disease · 0 citations