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Ge-Fei Chen

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Open access Oct 2026

Two functionally distinct amyloid-β intermediates link aggregation pathways to pathology in Alzheimer’s disease

Neurotoxic intermediates formed during amyloid-β(Aβ) aggregation are thought to drive Alzheimer’s disease, yet their rarity and transient nature have obscured their identity and formation pathways in the human brain. Here, we combine super-resolution microscopy and single-molecule functional imaging with kinetic modell...

Agnieszka Urbanek, A. Dear, David P. Rhodes et al. · 0 citations
Sep 2026

Rational design, synthesis, and biological evaluation of indole-piperazine based α-ketoamide derivatives as dual Aβ and tau aggregation modulators for Alzheimer's disease.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by pathological aggregation of amyloid-β (Aβ) and tau proteins, representing two major hallmarks of disease progression. Targeting both aggregation pathways simultaneously offers a promising therapeutic strategy. Building upon our previo...

Bhanuranjan Das, Anurag T. K. Baidya, Deepak Chouhan et al. · 0 citations

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