TIR (Toll/interleukin-1 receptor) domains are central components of innate immunity and cell-death pathways across diverse forms of life. In bacteria, TIR domain-containing proteins participate in diverse antiphage defence systems, several of which rely on NADase activity carried out by TIR domains. This nucleosidase a...
W. Gu, M. K. Manik, C. Jobichen et al.· bioRxiv· 0 citations
Background Archaeal extra-chromosomal elements (ECEs) play key roles in archaeal host biology and evolution, yet little is known about their diversity and interactions with each other. Here, we report 42 complete 66 - 165 kbp genomes: 23 “Klingons”, 8 “Romulans” and “Romulan-like elements”, and 11 “Ferengi”, three new...
Natasha J. Jablonsky, Ling-Dong Shi, Daniela S. Aliaga Goltsman et al.· bioRxiv· 0 citations
Lectin-like protein antibiotics (Llps) kill Pseudomonas by inhibiting BamA, the essential core of the β-barrel assembly machinery (BAM). Llps are composed of one or two β-lectin domains and a C-terminal peptide, with characterisation to date centred on the two-domain L-type pyocins of P. aeruginosa, which bind BamA ext...
Fabian Munder, Chun-Xiao Wang, Luis Jimenez et al.· bioRxiv· 0 citations
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