Gao-Yuan Ge

The deubiquitinase OTUD6B regulates cardiac hypertrophy by stabilizing TNF receptor associated factor 2.

AIMS Pathological cardiac hypertrophy serves as the primary pathological driver of heart failure, significantly impacting patient prognosis. Deubiquitinating enzymes, which play pivotal roles in protein homeostasis, are emerging as key regulators in cardiac hypertrophy and dysfunction. This study sought to elucidate th...