Gao-Hai Shao

Ferroptosis in osteoporosis: core mechanisms, cell-specific effects in bone remodelling, and therapeutic perspectives

Osteoporosis is an endocrine and metabolic bone disease driven by insufficient bone formation, enhanced bone resorption, and disrupted coupling of bone remodelling. Ferroptosis, characterised by iron-dependent membrane phospholipid peroxidation and failure of anti-lipid-peroxidation defences, is emerging as a mechani...