Author

Gao-Feng Liu

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Open access Aug 2026

CD200Fc attenuates LPS-induced neuroinflammation and motor deficits via modulation of microglial activation and autophagy

This study investigated the therapeutic potential of CD200Fc in a mouse model of chronic neuroinflammation induced by intraperitoneal lipopolysaccharide (LPS) injections administered every other day for four weeks. Wild-type mice (Male mice aged 8 weeks) were divided into four groups: WT + PBS, WT + LPS, LPS + PBS,...

Wenjie Ma, Chun-Xiao Bai, Xiao-Chuan Qi et al. · Scientific Reports · 0 citations

Sep 2026

c-Cbl overexpression alleviates pathological damage in Parkinson's disease by suppressing NLRP3 inflammasome-mediated neuroinflammation via the NF-κB signaling pathway.

Parkinson's disease (PD), the world's second most prevalent neurodegenerative disorder, is characterized by midbrain substantia nigra dopaminergic (DA) neuron loss, neuroinflammation, and α-synuclein aggregation. c-Cbl, a RING-finger E3 ubiquitin ligase highly expressed in the substantia nigra and striatum, regulates n...

Chun-Xiao Bai, Xiao-Chuan Qi, An-Heng Zhu et al. · Biochimica et Biophysica Act... · 0 citations