The activation, differentiation, effector functions, and memory formation of immune cells are not only regulated by signaling pathways and transcription factors but also profoundly depend on the dynamic reprogramming of their intrinsic metabolic states. Over the past decade, groundbreaking research in the field of immu...
The gut microbiota metabolite butyrate plays an important role in maintaining intestinal immune homeostasis, but it’s still unclear whether it can induce trained immunity in intestinal macrophages and thus affect anti-tumor immune responses. This study aimed to investigate the ability of butyrate to induce trained immu...
Gang Liu, Jia Wang, Li-Qiang An· Biology and Medical Engineer...· 1 citation
This study explores the reversal effect of targeting mitochondrial metabolic reprogramming on CD8⁺ T cell exhaustion within the tumor microenvironment and its synergistic mechanism when combined with immune checkpoint blockade therapy. B16-OVA melanoma and LLC lung cancer tumor-bearing mouse models were established. Us...
Gang Liu, Jia Wang, A. Vasiukevich et al.· Biology and Medical Engineer...· 0 citations
Tumor infiltration regulatory T cells (Tregs) mediate immune escape by highly expressing multiple inhibitory receptors, which is one of the key factors in resistance to existing immune checkpoint inhibitors. However, systematic screening of Treg-specific immune checkpoints within tumors remains lacking. This study aims...
Gang Liu, Jia Wang, Li-Qiang An· Injury and Rehabilitation Ca...· 0 citations
Abnormal release of mitochondrial DNA (mtDNA) and innate immune sensing play key roles in tumor immune regulation, but how they work together with ferroptosis is still unclear. This study aims to clarify the molecular mechanism of how mtDNA reshapes the tumor immune microenvironment in coordination with ferroptosis thr...
Gang Liu, Jia Wang, Li-Qiang An· Global Health Care· 1 citation
The effectiveness of immune checkpoint inhibitors (ICIs) heavily depends on the complex spatial interactions of cells within the tumor microenvironment (TME). However, existing predictive biomarkers generally lack spatial resolution and interpretability, making it difficult to guide clinical decisions or reveal actiona...
Gang Liu, Jia Wang, Jia Zhu· Intelligent & Human Futu...· 4 citations
This work is the first to use a multi-modal foundation model for neoantigen vaccines, overcoming the tumor-type-specific constraints of conventional approaches and facilitating joint modelling of immunogenicity and clinical efficacy, thereby offering an AI decision engine for precision cancer vaccine design that is app...
Gang Liu, Jia Wang, Jia Zhu· Global Health Care· 2 citations
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