BACKGROUND
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. However, the role of small ubiquitin-like modifier 2 (SUMO2), a core member of the small ubiquitin-like modifier (SUMO) family, regarding its expression patterns and metabolism-related functions in HCC remains inade...
Yu-Long Deng, Bei-Bei Huang, Yu-Xing Tang et al.· Frontiers in Bioscience· 0 citations
Cholangiocarcinoma (CHOL) is a highly heterogeneous and aggressive malignancy that is frequently diagnosed at an advanced stage because of the lack of early biomarkers, resulting in a poor prognosis. Although ANAPC1 overexpression has been reported in other cancers, its role and regulatory mechanisms in CHOL rema...
Ke-Jun Wu, Lei Wang, Yan-Ting Zhan et al.· Hereditas· 0 citations
Cross-sectional analysis of NHANES 2007–2018 cross-sectional data found no overall association between sleep disorders and BC, and Mendelian randomization provided suggestive evidence of a modest association between genetically predicted sleep disorders and ER−, but not ER+, BC.
Si-Yan Chen, Jian-Di Li, Ke-Jun Wu et al.· World Journal of Oncology· 0 citations
This study identified GPATCH4, CCT3, C19orf53, UACA, PPM1M, and LIN37 as key genes mediating TKI resistance in HCC, and identified Ferroptosis, epithelial‐mesenchymal transition and hypoxia were new research directions, which were closely related to the pathways investigated in this study.
Siyi Chen, Li-Hua Yang, Zi-Qian Liang et al.· Cancer Medicine· 0 citations
NOL12 may be regulated by the putative miR‐1246‐5p/H3K27ac enhancer axis and promotes HCC progression through the spliceosome pathway, supporting its potential as a novel therapeutic target for HCC.
Li Xiao, Yu-Long Deng, Li-Na Liang et al.· IET Systems Biology· 0 citations
In vitro and limited xenograft data indicate that NC restrains CRC growth chiefly through the RAD21–KIF11 axis; KIF11 represents a promising preclinical target, though comprehensive systematic in vivo pharmacodynamic and translational animal validation remains absent in the current study and requires further independen...
New insights are provided into the differential expression and pathogenesis of LACTB2 in digestive tract tumours, particularly its prognostic and diagnostic value in GC.
Wei Zhang, Yushan Tang, Yi-Yang Chen et al.· Frontiers in Immunology· 0 citations
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