Gandi Sony Pears

Machine learning-guided discovery of a novel natural CDK7 inhibitor for triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited targeted therapeutic options; while sacituzumab govitecan and PARP inhibitors (for BRCA-mutated TNBC) have received regulatory approval in specific patient subgroups, the majority of TNBC patients continue to lack effective targete...