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Single-cell Atlas Reveals Myelopoietic Bias and Immunosuppressive Reprogramming in Metastatic Bone Marrow Across Cancers.
Bone metastasis can remodel the bone marrow microenvironment, yet how metastatic tumors reshape hematopoiesis and immunity across marrow regions remains poorly defined. Here, we profile a cross-cancer single-cell atlas with 126,986 cells by integrating bone marrow samples (tumor, involved, and distal sites) from liver,...