Gabriele Giachin

A hierarchically organized communication network underlies kinetic allostery in SARS-CoV-2 Mpro.

The SARS-CoV-2 main protease (Mpro) is an essential viral enzyme whose catalytic activity strictly depends on dimerization and inter-protomer functional communication. While hundreds of symmetrical ligand-free or fully occupied structures are available, the structural and dynamical mechanisms governing asymmetric long-...