Gabriele Capriglia

Accelerated Adaptive Evolution of Gram‐Negative Bacteria With a Broad‐Host‐Range Dual Base Editor

ABSTRACT Adaptive laboratory evolution (ALE) is a powerful strategy for exploring functional solution spaces, yet its pace is fundamentally constrained by low spontaneous mutation rates. Here, we present a broadly applicable genetic device that accelerates genome diversification in Gram‐negative bacteria through the tr...