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Gabriel Salles

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#protein folding Open access Sep 2026

Structural Analysis of NR1H3 Variants (R415Q, P199H, S440C) Reveals Residue-Specific Grounding for RXR-Interface Disruption in Familial Multiple Sclerosis (MS)

Familial Multiple Sclerosis (MS) has been proposed to exhibit a biological association with the R415Q mutation in the Liver X Receptor Alpha (LXRA) protein, in which the subsequent localized discrepancies on the protein's structure are alleged to disrupt heterodimerization (Salles, in review). Unlike R415Q, other NR1H3...

Gabriel Salles · 0 citations
#protein folding Open access Sep 2026

Structural Analysis of NR1H3 Variants (R415Q, P199H, S440C) Reveals Residue-Specific Grounding for RXR-Interface Disruption in Familial Multiple Sclerosis (MS)

Familial Multiple Sclerosis (MS) has been proposed to exhibit a biological association with the R415Q mutation in the Liver X Receptor Alpha (LXRA) protein, in which the subsequent localized discrepancies on the protein's structure are alleged to disrupt heterodimerization (Salles, in review). Unlike R415Q, other NR1H3...

Gabriel Salles · 0 citations

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