Author

Gabriel Marc

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Open access Oct 2026

Comparative Phytochemical and Biological Evaluation of Walnut Septum and Pellicle Extracts in Chemical, Computational, and Cell-Based Models

Background: Walnut (Juglans regia L.) processing generates polyphenol-rich by-products, including the septum (WS) and pellicle (WP). This study comparatively characterized the phytochemical composition of WS and WP from Romania and investigated their antioxidant and preliminary immunomodulatory properties using chemica...

Letiția Mateș, Denisia Pașca, I. Fizeșan et al. · Pharmaceuticals · 0 citations

Open access Oct 2026

Synthesis, Antioxidant Activity, In Silico Evaluation, and Cytotoxicity of Novel Polyphenolic–Methyliden–Hydrazono–Thiazole Derivatives

Novel thiazolyl–polyphenolic derivatives were designed and synthesized to investigate the influence of aromatic substituents on antioxidant activity, molecular properties, and cytotoxicity. Eight derivatives (E1–E8) were synthesized by a Hantzsch reaction and their structures were confirmed by MS, FT-IR, and 1H/13C NMR...

A. Cornea, Gabriel Marc, I. Fizeșan et al. · Molecules · 0 citations

Open access Sep 2026

Synthesis, molecular dynamics, and antimicrobial evaluation of peptide-antibiotic conjugates designed for dual-mechanism pathogen inhibition

These in vitro assays demonstrate retained peptide membrane-disrupting properties and synergistic effects with the antibiotics, and represents a promising strategy to reduce toxicity and overcome antimicrobial resistance.

Denisa Leonte, Clemence Fartaoui, Ioana Ionuț et al. · Frontiers in Pharmacology · 0 citations