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Open access Sep 2026

Transcriptomic characterization of transitional B cells reveals four subsets with perturbed activation profiles in scleroderma

Summary We previously demonstrated that patients with scleroderma or systemic sclerosis (SSc) have elevated autoreactive transitional B cells, including against topoisomerase I (anti-topoisomerase I autoantibody [ATA+]). This suggests that defective transitional B cell tolerance could drive autoimmunity in SSc. To inve...

Claire F. Beesley, Nina R. Goldman, Gisela Gabernet et al. · 0 citations
Open access Jul 2026

Adaptive Immune Receptor Repertoire Knowledge Commons: data harmonization 2309859

A CDM for the Adaptive Immune Receptor Repertoire Knowledge Commons was designed based upon the Ontology for Biomedical Investigations, a community standard for scientific data integration, and the LinkML data modeling language was used for implementation.

Scott Christley, Felix Breden, Kevin A. Burns et al. · 0 citations

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