G. Wegener

630. Identification of brain structures involved in fear memory-induced depressive-like behaviours

Abstract Background Post-traumatic stress disorder (PTSD) is a psychiatric condition that develops from experiencing trauma. It is characterised by dysregulated fear-memory processing, leading to overconsolidated, generalised and persistent fear. Within the amygdala-hippocampus-prefrontal cortex fear circuit alteration...

High-intensity fear engrams extend beyond threat processing to drive cognitive and affective dysfunction

618. Modulation of hippocampal fear engrams reveals circuit mechanisms linking maladaptive fear, memory deficits, and depressive-like behaviour

Abstract Background Classic PTSD symptoms have been linked to maladaptive fear memory processing, involving fear generalization and impaired extinction learning. In contrast, cognitive and mood symptoms remain understudied, and their link to fear-related mechanisms is unclear. Aims & Objectives Here, we investigate the...

495. Differential effects of social and non-social chronic stress on mPFC activity during cognitive processing

Abstract Background Cognitive impairment is a core feature of major depressive disorder and is associated with greater severity and resistance to antidepressant treatment. Dysfunction of the medial prefrontal cortex (mPFC), a region essential for cognitive control, emotional regulation, and motivational decision-making...

269. Resolution of inflammation in metabolic mood disorders

This project addresses a major therapeutic gap by directly targeting the resolution of inflammation rather than suppression of inflammatory pathways by directly targeting the resolution of inflammation rather than suppression of inflammatory pathways.