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Open access Oct 2026

Pyrrolocytosine as a Fluorescent Sensor of RNA-Small Molecule Interactions

Fluorescent base analogues have proven to be valuable probes of RNA structure. Pyrrolocytosine (pC), an analogue of cytosine, exhibits highly environment-sensitive fluorescence within RNA and is strongly quenched in hydrogen-bonded contexts. In this work, we incorporated pC into the aptamer domain of the B. subtilis gu...

Taylor L. Coulson, G. Valdez, J. Widom · 0 citations

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