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Review Sep 2026

The Dual Role of Cholesterol Metabolism in Hepatocellular Carcinoma: Mechanisms, Therapeutic Strategies and Future Perspectives

This review explores cholesterol-targeting therapeutics like Statins, ezetimibe, SQLE inhibitors, SOAT1 inhibitors, and PCSK9 modulation, which demonstrate promising anti-cancer potential, yet therapeutic efficacy is limited by metabolic feedback mechanisms and tumor heterogeneity.

Rajabhuvaneswari Ariyamuthu, Mahalakshmi Mani, Jeevalatha Rugmangathan et al. · 0 citations

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