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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

G. Tomaras

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Open access Oct 2026

Correlates of Protection and Response Durability of the RTS,S Vaccine in Four Malaria Challenge Studies

RTS,S/AS01 (RTS,S) is one of two WHO-recommended malaria vaccines for children in moderate-to-high transmission settings. Yet, no validated immune correlate of protection (CoP) has been established for this vaccine. We selected 16 biomarkers to further assess as candidate CoPs, based largely on their ability to well-pr...

S.-Y. Kim, T. Linnekin, L. Carpp et al. · 0 citations
Open access Sep 2026

Preferential engagement of the anti-inflammatory ATP/adenosine axis by HIV vaccine candidate with V1-deleted envelope in male rhesus macaques

Ex vivo, ΔV1 gp120 reduced CCR5 expression on CD4+ T cells relative to WT gp120, consistent with the anti-inflammatory mucosal response by ΔV1-vaccine regimens in vivo, promotes an anti-inflammatory mucosal landscape less permissive to HIV seeding and dissemination following virus exposure.

Isabela Silva de Castro, Mohammad Arif Rahman, Massimiliano Bissa et al. · 0 citations
Open access Jul 2026

Rapid and robust immune response boosting with potent, next-generation adjuvant in viral vector-primed primates

A modified HIV-1 vaccine regimen incorporating next-generation adjuvants to improve immune responses and vaccine efficacy in a gold standard, pre-clinical primate model indicated that novel adjuvants represent a promising strategy for improving immune responses to protein immunogens.

Hannah A. D. King, C. Subra, Emily Tourtellott et al. · 0 citations

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