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Author

G. Tofaris

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2 papers indexed here

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Open access Sep 2026

Electronic profiling of neuronal extracellular vesicles enables early prediction of Parkinson’s disease

Misfolded alpha-Synuclein (α-Syn) accumulation is the defining molecular pathology of Parkinson’s disease (PD), yet blood-based assays remain challenged by the high background of peripheral α-Syn originating mainly from red blood cells. Neuronal extracellular vesicles (EVs) circulating in blood offer a biologically enr...

Tian-Rui Chang, Cheng Jiang, Shi-Jun Yan et al. · 0 citations
Open access Aug 2026

α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson’s disease

The primary mechanism and subcellular localisation of α-synuclein toxicity in Parkinson’s disease pathogenesis remain unknown. We spatially and temporally resolved proteomic and transcriptomic changes in human iPSC-derived dopaminergic neurons with increasing burden of pathological α-synuclein. We found that misfolded...

Chor Lai Lam, N. Gatford, Ana Aragón-González et al. · 0 citations

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