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Review Open access Sep 2026

Fenofibrate in ophthalmology: therapeutic efficacy and mechanisms

Ophthalmic diseases are a growing global cause of visual impairment, driven by population aging and the rising prevalence of diabetes mellitus. Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPARα) agonist widely used for dyslipidemia, has emerged as a candidate for therapeutic repurposing in ophthalm...

Sean Chung-Hei Ho, I. Lee, Chang Liu et al. · 0 citations
Open access Aug 2026

Macular Choriocapillaris and Retinal Microvascular Alterations Across the Prediabetes–Early Type 2 Diabetes Continuum

Macular microvascular impairment begins in prediabetes, and among OCTA metrics, choriocapillaris FD density showed the strongest discriminatory ability and was the most influential feature in SHAP analysis, suggesting greater sensitivity of choriocapillaris metrics for monitoring early metabolic disease.

Fang Zheng, Yueheng Hong, Jacqueline Chua et al. · 0 citations

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