Therapeutic adaptive responses and secondary resistance represent major obstacles to effective colorectal cancer treatment. These dynamic adaptations arise within a permissive tumor microenvironment that sustains cancer cell survival, epithelial-mesenchymal plasticity and the outgrowth of drug-tolerant clones, ultima...
Kimiya Shams, Francesco Verona, Ornella Roberta Brancato et al.· Cell Death Discovery· 0 citations
This chapter explores the biomedical significance of ceRNAs, highlighting their role in modulating gene expression and their potential implications in disease, and summarizes available tools, resources, and practical examples for studying lncRNA-miRNA interactions to aid researchers in navigating this sophisticated reg...
Francesco Orilio, R. Brancaccio, Francesco Verona et al.· Methods in molecular biology· 0 citations
Findings suggest a dynamic, reversible model of chemoresistance driven by EMP rather than fixed cell identity, which may support the development of treatment strategies that limit resistance and improve patient response to perioperative chemotherapy.
Laurie Clauzon, Kimiya Shams, Roberta Drago et al.· Diseases of the esophagus· 0 citations
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