Author

G. Silverman

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Aug 2026

Sequalae and reversal of age-dependent alterations in mitochondrial dynamics via autophagy enhancement in reprogrammed human neurons.

A mechanism by which aging reduces autophagic flux secondary to a loss of neuritic lysosomes, resulting in mitochondria-intrinsic mechanisms to avoid loss of energy production is revealed.

Eva Klinman, Ji-sun Kwon, Roland E. Dolle et al. · Autophagy · 0 citations

Open access Jul 2026

Cross-species functional analysis of a de novo DCLK1 variant associated with a neurodevelopmental disorder

The findings implicate DCLK1 in a previously unrecognized progressive neurodevelopmental disorder and demonstrate the power of integrative cross-species functional genomics in resolving ultra-rare disease variants.

Stephen C. Pak, David Butler, Wei-Xi Yuan et al. · Research Square · 0 citations