Author

G. Schmitt-Ulms

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Open access Oct 2026

Antithetical roles of tau in hippocampal long-term synaptic depression in rats versus mice

Synaptic dysfunction is a primary feature of tauopathies, a group of major neurodegenerative diseases that includes Alzheimer’s disease. However, the normal synaptic functions of tau are poorly understood. Since rats provide advantages over mice for understanding human tau, such as expressing six tau isoforms and showi...

Liam T. Ralph, Eric W. Salter, Patrick Tidball et al. · Molecular Brain · 0 citations

Open access Sep 2026

PRNP mutations initially generate an alternatively misfolded PrP species that dissuades prion replication

Mutations in the PRNP gene, which encodes the prion protein (PrP), cause genetic prion disease. However, how PRNP mutations lead to spontaneous prion formation remains poorly understood. Building off the observation that expression of mutant bank vole PrP (BVPrP) in mice causes spontaneous prion disease, we sought to i...

Genki Amano, H. Arshad, Surabhi Mehra et al. · bioRxiv · 0 citations

Open access Aug 2026

The protein disulfide isomerase P4HB/PDIA1 modulates cellular and misfolded forms of the prion protein

It is shown that stable knock-down of the protein disulfide isomerase P4HB in prion-susceptible CAD5 cells reduces PrPC levels and hinders the generation of protease-resistant PrP (PrPres) following infection with two different prion strains.

Genki Amano, H. Arshad, Zeel Patel et al. · PLoS Pathogens · 0 citations