Articular cartilage (AC) repair remains a major clinical challenge due to its limited healing capacity and the inability of current treatment strategies to restore long-term function. Biomaterial-based strategies which support favorable immune responses and appropriate progenitor cell function have shown promise in enh...
S. O'Rourke, G. Gonnella, G. S. Kronemberger et al.· Journal of Biomedical Materi...· 0 citations
Collagen fiber organization is critical to the biomechanical function of musculoskeletal tissues. This has motivated increased interest in tissue engineering strategies aiming to recapitulate native collagen architecture in order to generate more biomimetic grafts. In particular, three-dimensional (3D) bioprinting has...
A. Karam, G. S. Kronemberger, Daniel J. Kelly· Tissue engineering. Part B,...· 0 citations
Osteochondral repair requires restoration of zonally organised articular cartilage and subchondral bone, yet translatable implants rarely reproduce this spatial complexity. Here, we developed an acellular multilayer scaffold comprising a superficial 2% (w/v) articular cartilage extracellular matrix (AC-ECM) phase, an i...
G. Gonnella, O. Strong, V. M. Sularea et al.· bioRxiv· 0 citations
Repairing osteochondral defects remains a significant clinical challenge due to the distinct requirements for regenerating both articular cartilage and the underlying subchondral bone. The goal of this study was to evaluate a multi-phase scaffold that combined melt electrowriting (MEW) and fused filament fabrication (F...
R. Gibney, Marcin Kotlarz, K. Eichholz et al.· Biomedical Materials· 0 citations
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