Author

G. Riboldi

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Open access Sep 2026

Peripheral Immune Alterations and T Cell Clonal Dynamics Across the Parkinson’s Disease Spectrum

The role of peripheral immunity in Parkinson's disease (PD) remains incompletely understood. Here, we performed paired single-cell RNA sequencing (scRNA-seq) and T-cell receptor (TCR) profiling of 630k peripheral blood mononuclear cells (PBMCs) from 168 donors spanning idiopathic and genetic PD, prodromal PD, and healt...

Mikaela Rosen, J. Majos, Daniele Mattei et al. · medRxiv · 0 citations

Open access Jul 2026

Data-Driven Biological Subtypes of Parkinson ' s Disease

This work proposes a biology-driven clustering in a large cohort if subjects with iPD if subjects belonging to the ''Mixed Pathology'' subtype included subjects whose biomarker signature did not indicate predominant alterations in any of the explored pathways.

Piergiorgio Grillo, Chan Wang, A. Pisani et al. · medRxiv · 0 citations