VANDAM: Viewing a nucleotide sequence with DNA molecular priors
Contemporary Genomic Foundation Models (GFMs) rely on a DNA-as-a-string paradigm that employs masked token prediction objectives for pretraining. However, this abstraction does not explicitly model the biochemical, structural, and physical properties essential to biological function. Many molecular properties can be es...
Jeremy Levy, Ariel Larey, Yury Nahshan et al.
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