BACKGROUND
Invasive lobular carcinoma (ILC) is known to exhibit distinct metastatic patterns compared with carcinoma of no special type (NST); however, little is known about its specific propensity for central nervous system (CNS) and leptomeningeal (LM) involvement, particularly in estrogen receptor (ER)-positive/huma...
F. Miglietta, C. Vernieri, T. Giarratano et al.· ESMO Open· 0 citations
Antibody-drug conjugates (ADCs) have progressively advanced the conceptual framework of targeted oncology, evolving from a way to deliver chemotherapy selectively to tumor cells into drugs that also interact with the immune system to support their action. In breast cancer, the approval of several novel ADCs has transfo...
A. Mattana, C. Veronese, Julia Penitenti et al.· Frontiers in Immunology· 0 citations
Effectiveness of first-line ET plus CDK4/6i in patients with HR+/HER2− aBC worsens progressively with decreasing ERα expression, and PgR expression adds further prognostic discrimination, with low ERα and PgR expression identifying a subgroup of patients with particularly poor outcomes.
F. Ligorio, L. Provenzano, R. Caputo et al.· EClinicalMedicine· 0 citations
Lynch syndrome–associated urothelial carcinoma (LS-UC) is a rare and undercharacterized clinical entity. While FGFR3 alterations are well described in sporadic urothelial carcinoma, their prevalence and clinical implications in LS-UC remain unclear. We aimed to provide a comprehensive clinical and molecular characteriz...
A. Rametta, M. Barella, A. Scardino et al.· Familial Cancer· 0 citations
Background Ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3/CD203c) is largely studied as a marker of mast cells and basophils. By depleting extracellular ATP, it prevents excessive activation of mast cells and basophils, hence reducing inflammation and allergic reactions. Recent findings have also shown that...
Roberta Bongiorno, Maria Teresa Majorini, Valeria Figà et al.· bioRxiv· 0 citations
It is proposed that MEK inhibitors may represent a relevant therapeutic option for BRAF fusions and non‐V600 BRAF mutant tumours, providing a novel strategy for this challenging disease.
Matilde Monti, Martina Brigida Romanello, L. Agnelli et al.· Journal of Pathology· 0 citations
In a large international real-world study of non-small cell lung cancer, a multimodal explainable AI model outperformed established biomarkers for immunotherapy outcome prediction and improved physician decision-making.
A. Prelaj, V. Mišković, Matteo Sacco et al.· Nature Medicine· 1 citation
Evidence supporting ctDNA for early response monitoring during neoadjuvant therapy, postoperative minimal residual disease detection, and longitudinal molecular surveillance is summarized and ctDNA‐guided therapeutic interception strategies and emerging multimodal cell‐free DNA approaches are discussed.
S. Di Cosimo, V. Appierto, C. Reduzzi et al.· Cancer· 0 citations
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