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G. M. Giuffré

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Sep 2026

APOE-centered transcriptional convergence underlying diverse dementia subtypes.

BackgroundDementia subtypes exhibit diverse clinical and pathological features, yet may share convergent molecular underpinnings. Identifying these common pathways is critical for unified therapeutic strategies.ObjectiveTo delineate the shared genetic architecture and convergent molecular pathways underlying diverse de...

Zhi-Jie Xu, Jie Ma, G. M. Giuffré et al. · 0 citations
Open access Sep 2026

Human amniotic mesenchymal stromal cell-derived extracellular vesicles reprogram microglia and prevent neurodegeneration in experimental models of Alzheimer’s disease

HAMSC-EVs exert robust anti-inflammatory and neuroprotective effects in both murine and human AD models, improving cognition, modulating glial activation, and restoring synaptic integrity, and highlight the translational potential of intranasal hAMSC-EVs as an adjuvant therapeutic strategy targeting neuro inflammation...

Andrea Papait, F. Natale, A. Silini et al. · 0 citations
Open access Aug 2026

Cognitive components derived from traditional neuropsychological tests and their associations with plasma p-tau217 and p-tau181 in mild cognitive impairment: a multisite analysis.

The findings indicate that a robust four-factor cognitive structure can be identified in clinically defined MCI cohorts without prior biological selection, and the association between latent memory factors and plasma p-tau217, observed primarily in cohorts with higher biomarker burden or clearer amnestic profiles, high...

Ana S. Perez, Hugo L. Hammer, V. Andersson et al. · 0 citations

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