Targeting the allosteric mechanism of methicillin-resistant Staphylococcus aureus pyruvate kinase: From inhibitor discovery to network reorganization.
Pyruvate kinase (PK) is a promising antimicrobial target against Methicillin-resistant Staphylococcus aureus (MRSA) due to its central role in bacterial metabolism. Building on previous virtual screening of three putative/known allosteric sites, we evaluated six FDA-approved compounds for effects on PK-associated enzym...