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Author

Gökşad Cemil Kotan

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5 papers indexed here

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Open access Oct 2026

Dose-Related Effects of Cannabidiol on Inflammatory and Redox Responses, Bacterial Dissemination, and Multiorgan Injury in CLP-Induced Septic Rats

Background: Sepsis couples dysregulated inflammation, oxidative imbalance, microbial dissemination, and multiorgan injury. Cannabidiol (CBD) has anti-inflammatory and redox-modulating properties, but its dose-related effects in polymicrobial sepsis, particularly alongside culture-recoverable bacterial burden, remain in...

Ufuk Ülker, B. Bayraktar, T. Karan et al. · 0 citations
Open access Oct 2026

Annona muricata Leaf Extract Rebalances Systemic Redox Status and Modulates Neuroimmune, Microbial, and Functional Responses in CLP-Induced Septic Rats

Oxidative stress, immune dysregulation, and disturbed metabolic adaptation contribute to early sepsis pathophysiology. This exploratory study evaluated a commercial Annona muricata leaf extract in 40 male rats assigned to five groups (n = 8/group): healthy Control, laparotomy-only Sham, untreated cecal ligation and pun...

Ufuk Ülker, B. Bayraktar, M. Alçığır et al. · 0 citations
Open access Oct 2026

Pomegranate Peel Extract and Punicalagin Are Associated with Attenuated Intestinal Barrier Dysfunction, Oxidative Stress, and Multi-Organ Injury in a Rat CLP Model

These biomarker-based and survival findings support further preclinical investigation of standardized pomegranate-derived preparations as potential adjunctive interventions; they do not establish direct intestinal permeability, mitochondrial restoration, clinical therapeutic efficacy, or a punicalagin-mediated mechanis...

Mustafa Yeni, Hilal Ürüşan, B. Bayraktar et al. · 0 citations
Open access Sep 2026

Effects of Hawthorn Fruit Extract Administration on Asprosin, Thyroid Hormones, and Nutritional Performance in Diabetic Rats

This study aimed to determine the effects of hawthorn fruit extract (HFE) administration on asprosin and thyroid hormone (T3, T4, and TSH) responses, as well as on feeding behavior and feed efficiency performance in experimentally induced Type 1 diabetic rats. Sixty-four male Wistar Albino rats used in the study were a...

Ümmü Gülşen Bozok, Gülbahar Böyük Özcan, B. Bayraktar et al. · 0 citations

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