Author

G. K. Sandve

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Open access Aug 2026

Naïve adaptive immune receptor repertoires in celiac disease assessed by machine learning; impact of the HLA-DQ2.5 allotype on the TCR repertoire

The adaptive immune receptor repertoire (AIRR) - the collection of an individual’s B-cell and T-cell receptors (BCRs and TCRs, respectively) - encodes cumulative immune history and is shaped by both germline genetics and environmental exposures. Skewed repertoires have been linked to infections, vaccination responses a...

A. Officer, Ida Lindeman, Milena Pavlović et al. · Immunogenetics · 0 citations

Open access Sep 2026

Single-cell immune repertoire atlas maps coordinated circulating adaptive immune states in inflammatory bowel disease

Single-cell studies have defined immune states in inflammatory bowel disease (IBD), but how adaptive receptor histories organize circulating immunity remains unclear. We generated a single-cell transcriptomic atlas of peripheral blood from 249 participants with Crohn’s disease, ulcerative colitis, or non-IBD control st...

J. Gubatan, Jia-Yu Ye, Christin Lund-Andersen et al. · bioRxiv · 0 citations

Open access Jul 2026

What Do Generative Models Learn About Adaptive Immune Receptor Repertoires? A Benchmark Study

A suite of evaluation metrics tailored to AIRR sequence data are applied and a systematic comparison of popular generative model families proposed for the AIRR field, including variational autoencoders, long short-term memory networks, antibody language models, selection models, and simple statistical baselines are pre...

C. Wurtzen, Maria Mamica, C. Kanduri et al. · bioRxiv · 0 citations