Patients with advanced Parkinson’s disease (PD) often need to continue with device-aided therapies (DAT), such as intestinal and subcutaneous infusion therapies. Recently, continuous subcutaneous administration of foslevodopa/foscarbidopa (LDp/CDp) has emerged as a new therapeutic method. Two years after its approval i...
D. Weise, Tobias Warnecke, Carsten Buhmann et al.· Neurological Research and Pr...· 0 citations
BACKGROUND
Down syndrome (DS) entails widespread age-related functional decline affecting multiple organ systems, including genetically determined early-onset Alzheimer disease (DSAD), resulting in an increased vulnerability to frailty early in life. We investigated the relationship between frailty, cognition and intel...
Georg S. Nuebling, Lena Marth, K. Sandkühler et al.· Journal of Intellectual Disa...· 0 citations
Ongoing research aims to establish sensitive biomarkers, identify prodromal disease stages, and develop targeted interventions addressing key pathophysiological mechanisms such as α-synuclein aggregation and neuroinflammation.
I. Wilkens, Sabrina Katzdobler, A. Bernhardt et al.· Fortschritte der Neurologie...· 1 citation
In CSF-confirmed participants, age emerged as the most consistent predictor of plasma biomarker levels, particularly NFL and pTau181, which suggests that plasma biomarkers are influenced primarily by age and genetic background rather than by metabolic factors in this cohort.
Carolin I. Kurz, Marleen Taute, Paulina Tegethoff et al.· Aging Brain· 0 citations
Background Progressive supranuclear palsy (PSP) is a primary tauopathy defined by the accumulation of 4R tau isoforms in neurons, oligodendrocytes and astrocytes. Despite evidence of genetic susceptibility operating through glial cell types, it remains poorly understood how cell type-specific epigenetic-transcriptional...
N. Briel, Viktoria C. Ruf, Paul L. C. Feyen et al.· bioRxiv· 0 citations
Bridging advances in pathophysiology with patient-centred care will be essential for improving outcomes in MSA, and advances in fluid biomarkers and multimodal imaging are expected to facilitate earlier detection, improve diagnostic accuracy, and provide more robust tools for monitoring disease progression.
J. Buonocore, Bianca Calió, Fabian Leys et al.· Journal of neural transmissi...· 0 citations
It is shown that early complement associated pruning of inhibitory synapses precedes overt α-synuclein aggregation and neuronal loss in prodromal synucleinopathy, indicating disease-context dependent relationships between αSyn pathology and neurodegeneration.
Svenja-Lotta Rumpf, Felix L. Strübing, Karsten Nalbach et al.· Nature Communications· 0 citations
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