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Author

G. Hailu

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Review Open access Aug 2026

Deubiquitinase-targeting chimeras (DUBTACs): a game-changing approach for targeted protein stabilization in drug discovery.

Targeted protein degradation (TPD) has transformed drug discovery by enabling event-driven elimination of pathogenic proteins, but many diseases arise from protein insufficiency and require restoration rather than removal. Deubiquitinase (DUB)-targeting chimeras (DUBTACs) offer a complementary proximity-pharmacology ap...

G. Hailu, Emanuele Fabbrizi, Andrea Mancini et al. · 0 citations
Review Open access Jul 2026

METTL1/WDR4 Complex: A Novel Epitranscriptomic Target at the Crossroads of RNA Methylation and Drug Discovery

Advances provide the first chemical foothold for therapeutic modulation of m7G pathways and underscore METTL1 as a promising yet complex target requiring careful biological stratification.

Emanuele Fabbrizi, Gebremedhin S. Hailu, Andrea Mancini et al. · 0 citations

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