Cortical thickness signature of early-onset Alzheimer’s disease across clinical stages and A/T1 biomarker profiles
The cortical thinning signature of early-onset Alzheimer’s disease (EOAD) is well established in dementia, but its emergence during earlier disease stages remains unclear. We investigated when it becomes detectable and whether it differs according to fluid amyloid and phosphorylated-tau (A/T1) biomarker profiles. We st...