Open access
Oct 2026
Effects of SGLT2 inhibition on cardiac remodeling and heart failure development in aortic stenosis rats
Aortic stenosis (AS) is increasingly prevalent in ageing populations, yet no pharmacological therapy has been shown to modify its progression to heart failure (HF). Sodium glucose cotransporter 2 (SGLT2) inhibitors improve outcomes in HF, but their effects in pressure overload-induced cardiac remodeling remain unclear....
L. Pagan, M. J. Gomes, M. Gatto et al.
· Molecular Biomedicine · 0 citations