Author

G. Fragiadakis

2 papers indexed here

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Open access Oct 2026

Advancing CD38 from a marker of disease activity to an active regulator of interferon responses in juvenile dermatomyositis

Juvenile dermatomyositis (JDM), the most common pediatric inflammatory myopathy, is driven by an overactive immune signaling pathway called type I interferon. Current treatment relies on broadly immunosuppressive agents that lack mechanistic specificity, often fail to achieve durable disease control, and can result in...

Brittany A. Moser, Chioma J. Madubata, Marissa Y. Chou et al. · bioRxiv · 0 citations

Open access Sep 2026

Single-cell RNA sequencing of peripheral blood defines two immunological subtypes of Sjögren's disease distinguished by anti-SSA antibodies and aberrant B cell populations.

A two-disease model of SjD is supported and transitional B cells are highlighted as both a key biomarker and a therapeutic target, highlighting substantial biological heterogeneity within SjD.

G. Urbanski, K. Taylor, E. Flynn et al. · Arthritis & Rheumatology · 0 citations