Abstract Background Animal studies show that stress triggers immune dysregulation, leading to elevated levels of pro-inflammatory cytokines and microglial activation. This response is linked to excessive synaptic pruning and reduced synaptic density, potentially raising vulnerability to mental illness. In humans, child...
M. Zilberman, E. Vieira, C. Côté et al.· International Journal of Neu...· 0 citations
Abstract Background Over four decades of research have linked synaptic pathology to a broad range of brain disorders. Postmortem studies in conditions like psychosis spectrum disorders, Parkinson’s and Alzheimer’s Disease (AD) show changes in synaptic integrity but are confounded by factors such as illness duration or...
G. Mirfallah, C. Schifani, D. Shateri et al.· International Journal of Neu...· 0 citations
Abstract Background Schizophrenia spectrum disorders (SSDs) are chronic conditions associated with profound functional impairment, disability and economic burden. Traditional approaches to diagnosis and management often struggle to capture the heterogeneity of SSD. In recent years, machine learning (ML) has expanded ra...
Laura A. Rivera, Kenya A. Costa-Dookhan, Vijai Raj et al.· BMJ Open· 0 citations
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