Author

G. De Simone

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Open access Sep 2026

258. Metabolic connectomics and brain dynamics in schizophrenia: a novel perspective on treatment resistance and clinical response

Abstract Background Around 30% of schizophrenia patients fail to respond to standard antipsychotic treatments, a condition named treatment-resistant schizophrenia (TRS). While altered functional connectivity has been extensively studied in this population, research has predominantly relied on fMRI-derived hemodynamic s...

G. De Simone · International Journal of Neu... · 0 citations

Open access Sep 2026

30. Brain hypometabolism and disorganization domain as putative neuronal correlates in schizophrenia: a comparative head-to-head treatment-resistant vs. treatment-responsive schizophrenia PET study

Abstract Background About a third of schizophrenia patients are refractory to antipsychotics, a condition characterized by poor clinical and functional outcomes known as treatment-resistant schizophrenia (TRS). The disorganization domain may represent the leading factor in categorizing a schizophrenia patient as affect...

M. Ciccarelli, F. Iasevoli, A. Barone et al. · International Journal of Neu... · 0 citations

Open access Sep 2026

243. Dysconnectivity in schizophrenia: evidence at the molecular level via a network analysis of postmortem tissues

Abstract Background Schizophrenia pathophysiology has consistently been associated with disruptions in the glutamatergic pathway, postsynaptic density (PSD) proteins, and monoaminergic neurotransmission, especially the dopaminergic one. Proper functionality of each neurotransmitter system is crucial for brain health, b...

G. De Simone, T. Nuzzo, A. di Maio et al. · International Journal of Neu... · 0 citations