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Author

G. Challis

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2 papers indexed here

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Open access Aug 2026

A bacterial metabolite rewires fungal metabolism, triggering the hyphae-to-yeast transition.

Fungi transition between cell morphologies to adapt to and colonize environments. For Candida albicans, commensal colonization of humans and virulence depend on a reversible switch between invasive hyphae and disseminating yeast cells. The yeast-to-hyphae transition is well understood, but comparatively little is known...

Manasa Bharathwaj, Vinzenz Hofferek, Angavai Swaminathan et al. · 1 citation
Open access Aug 2026

Carbene Footprinting and Mass Spectrometry Capture Global Conformational Changes in Elongation Factor-Tu Induced by Antibiotic Binding

Carbene footprinting methodology, in combination with mass spectrometry, was employed to study the interactions of bacterial elongation factor-thermo-unstable (EF-Tu) with two antibiotics. EF-Tu, a GTPase, delivers aa-tRNA to the ribosome during protein synthesis where it undergoes a significant conformational switch...

Cameron Baines, Daniel C L Van, Lona M. Alkhalaf et al. · 0 citations

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