Review
Open access
Aug 2026
Neurobiological and Molecular Mechanisms of Cannabidiol in Depressive Disorders: A Preclinical Systematic Review
Findings highlight the multifactorial antidepressant potential of CBD and its analogs, suggesting a role as adjunctive or alternative therapies for mood disorders, however, further randomized controlled trials in humans are essential to confirm efficacy, safety, and optimal dosing parameters for clinical use.
Graziele Larissa Fontes Alves, Desyreé de Farias Gonçalves, P. C. de Oliveira et al.
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