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Author

G. Carleton

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Open access Aug 2026

PRDX1 regulates T cell effector function in the ovarian tumor microenvironment

T cell-based immunotherapies have remained ineffective against high-grade serous ovarian carcinoma (HGSOC). The metabolic environment of HGSOC suppresses the activity of cellular therapies, however, the metabolites that enhance or suppress T cell antitumor activity are not fully understood. Here, a pooled CRISPR-Cas9 k...

Sarah J. McPhedran, G. Carleton, Scott Hannan et al. · 0 citations

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