Author

G. Beckham

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Open access Aug 2026

Expanding the catabolic capacity of Pseudomonas putida to acetovanillone, 5-carboxyvanillate, and vanillyl glyoxylate for muconate production from kraft lignin-derived aromatics

The pulp and paper industry produces large volumes of condensed kraft lignin, which is challenging to convert to single chemical products. For this purpose, tandem chemical depolymerization and bioconversion to a single atom-efficient product is a potentially promising strategy. In this study, we conducted copper-catal...

Kathryn M. Mains, Dillon T. Hofsommer, Michael A. Gapuz et al. · bioRxiv · 1 citation

Open access Jul 2026

Pathway selection for arabinose utilization in Pseudomonas putida reveals a rate-yield tradeoff in muconic acid production from lignocellulosic sugars

This study presents a systematic comparison of sugar catabolic pathways that enabled development of strains suited for the tradeoffs between rate and yield and indicates that these performance metrics can reduce the minimum selling price of muconate-derived adipic acid and greenhouse gas emissions.

Dowan Kim, Torrey M Lind, Chen Ling et al. · bioRxiv · 1 citation

Open access Jul 2026

Simultaneous optimization of lignocellulosic sugar catabolism via systematic laboratory evolution under complex selection pressure

Efficient co-utilization of hexose and pentose sugars from lignocellulose is essential for microbial bioconversion, yet engineered catabolic pathways can be unstable or suboptimal in complex resource environments. Here, we use a Pseudomonas putida strain engineered to catabolize xylose and arabinose to examine how reso...

Sunghwa Woo, H. Lim, B. Norton-Baker et al. · Nature Communications · 0 citations

Open access Jul 2026

Engineered Pseudomonas putida reconfigures metabolic fluxes to support energy demands during muconate bioproduction from lignin-related aromatics

Pro proteomics, metabolomics, and 13C-fluxomics are applied to quantitatively compare central carbon and energy metabolism in wild-type P. putida and a muconate-producing strain for improved bioproduction from renewable feedstocks.

R. Wilkes, P. Suthers, A. Borchert et al. · bioRxiv · 3 citations

Open access Jul 2026

Overcoming protocatechuate and catechol accumulation in muconic acid production via adaptive laboratory evolution and metabolic engineering in Pseudomonas putida

Results indicate that catechol, not PCA, is the principal bottleneck in muconate production via the PCA decarboxylation route originally demonstrated by Draths et al., refining the understanding of pathway limitations and offering new strategies for improving rate, yield, and strain resilience in muconate bioproduction...

Alissa C. Bleem, Tracy L. Hodges, Torrey M Lind et al. · bioRxiv · 2 citations

Open access Jul 2026

Machine learning guided cell-free expression maps the biochemical landscape of carbonic anhydrase

This work demonstrates that integrating cell-free enzyme engineering with machine learning enables opportunities for high-throughput experimental measurements to benchmark and improve protein language models, accelerate design loops, and expand functional exploration within protein families where experimental informati...

J. Lazar, Evan Komp, I. Martínez et al. · bioRxiv · 1 citation