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Open access
Oct 2026
The PI3K/AKT/mTOR Pathway Is a Major Intracellular Regulator of Mast Cells Implicated in the Gut–Brain Axis and Mediates Inflammation
Phosphoinositide 3-kinase beta (PI3Kβ), phosphatidylinositol (3,4,5)-trisphosphate (PIP3), and phosphatase and TENsin homolog (PTEN) play crucial roles in the remodelling of cell junctions during infection. Remodelling of epithelial and endothelial junctions is a physiological effect aimed at maintaining barrier integr...
P. Conti, F. Mastrangelo, Armando Coppola et al.
· Gastrointestinal Disorders · 0 citations